PEDIATRIC IMMUNOLOGY. A CASE-BASED COLLECTION WITH MCQS, VOLUME 2

1. Introduction to Primary Immunodeficiencies
2. Workup of Recurrent Respiratory Infections and a Positive Family History
3. Pseudomonas Meningitis
4. Fever and Sleepiness
5. Recurrent Pneumonia
6. Developmental Regression
7. Recurrent Ear Infections and Pneumonia
8. Positive Urine Culture for Klebsiella pneumoniae
9. Brothers with Recurrent Sinopulmonary Infections and Chronic Lung Disease
10. Recurrent Infections and Arthritis
11. Initial Diagnosis of Neutropenia and Later Crohn’s Disease
12. Diagnosis of “Sweat-Chloride Negative” Cystic Fibrosis
13. Diagnosis of Sarcoidosis
14. Refractory Crohn’s disease
15. Asthma Which Was Not Asthma
16. Generalized Lymphadenopathy and Hypogammaglobulinemia After Abdominal Trauma
17. Weakness and Anemia
18. Normal Primary Care Workup for Recurrent Sinopulmonary Infections
19. Recurrent Sinusitis and Persistent Giardia Infection
20. Recurrent Respiratory Infections
21. Siblings Presenting with Mild and Severe Lymphoproliferation
22. Non-Malignant Lymphoproliferation
23. Portal Hypertension and Progressive Lymphoproliferation
24. Recurrent Otitis and Upper Airway Obstruction
25. Recurrent Pneumonia
26. A Growing BCG Lesion
27. Respiratory Distress and Hypoxemia
28. A Boy with Burdened Family History, Candidiasis and Diarrhea
29. Failure to Thrive
30. Recurrent Respiratory Infection and Hypereosinophilia
31. Neonatal Jaundice and Leukopenia
32. Microcephaly, Recurrent Infections and Failure to Thrive
33. Widespread Erythema and Skin Desquamation
34. Failure to Thrive, Rash and Fever
35. Autoimmune Cytopenia
36. Recurrent Respiratory Tract Infections
37. Protracted Diarrhea and Hypogammaglobulinemia
38. Gingivitis and Recurrent Tonsillitis
39. Respiratory Distress
40. Intestinal Cryptosporidiosis
41. Shortness of Breath
42. Pneumocystis jiroveci Pneumonia Without Failure to Thrive
43. Recurrent Infections and CNS Vasculitis
44. Recurrent Infections and Widespread Warts
45. Rash and Several Food Allergies
46. Severe Atopic Disease and Infections
47. Acute Mastoiditis
48. Chronic Papulovegetative Ulcer on Penis
49. Fever After DPT Vaccination
50. Recurrent Bronchiolitis
51. Oral Ulcers and Candidiasis
52. Neutropenia and Myelodysplasia
53. Loss of Appetite and Neutropenia
54. Delayed Umbilical Cord Separation
55. Recurrent Pneumonitis
56. Recurrent Sepsis, Leukocytosis and Bleeding Tendency
57. Maculopapular Rash on BCG Site
58. Recurrent Perianal Abscesses
59. Infected Hemangiomas
60. Recurrent Invasive Bacterial Infections
61. Cervical Lymphadenitis
62. Failure to Thrive and Nasal Obstruction
63. Inflammatory Bowel Disease and Frequent Skin Abscesses
64. Necrotizing Liver Granuloma
65. Constrictive Aspergillosis Pericarditis
66. Lung Abscess
67. Lethargy in a Toddler
68. Recurrent Cold Suppurative Granulomatous Lymphadenitis
69. Repetitive Fistulizing Lymphadenopathy and Hematochezia
70. Twins with Recurrent Candida Infections
71. Recurrent Stomatitis and Upper Respiratory Tract Infections
72. Oral Thrush and Onychomycosis
73. Oral Moniliasis and Failure to Thrive
74. Refractory Oral Thrush
75. Kidney Malformation and Persistent Neutropenia
76. Severe Pancytopenia
77. Silvery Hair
78. Fever and Blonde Skin
79. Probable Sepsis
80. Skin Abscess and Blonde Hair
81. Recurrent Infections and Easy Bruising
82. Fever and Skin Eruption
83. Cervical Lymphadenopathy and Nasopharyngeal Mass
84. Lymphadenopathy and Splenomegaly
85. Anemia and Neutropenia
86. Hemolytic Anemia and Lymphadenopathy
87. Recurrent Infections and Chronic Diarrhea
88. Recurrent Infections, Cytopenias and Lung Disease
89. Short Stature, Prolonged Fever and Lymphoproliferation
90. Siblings with Nail Dystrophy and Photophobia
91. Chronic Diarrhea and Failure to Thrive
92. Rash and Diarrhea
93. Recurrent Infections, Enteropathy and Granulomatous Lung Disease
94. Chronic Diarrhea
95. Early-Onset Inflammatory Bowel Disease
96. Recurrent Febrile Episodes and Abdominal Pain
97. Episodic Fever and Lymphadenopathy
98. Periodic Fever Syndrome and Developmental Delay
99. Periodic Fever and Maculopapular Rash
100. Long Episodes of Rash and Fever
101. Long-Lasting History of Urticaria
102. Rash and Fever since Two Weeks of Age
103. Aseptic Meningitis
104. Recurrent Fever and Sore Throat
105. Recurrent Fever and Stomatitis
106. Prolonged Fever and Swollen Joints
107. Skeletal Pain in Knee and Clavicle
108. Bone Pain in Upper Leg, Hip, Lower Back
109. Enterocolitis Followed by Recurrent Sepsis-Like Episodes
110. Recurrent Febrile Attacks, Myalgia and Livedo Reticularis
111. Sudden Dizziness, Somnolence and Diplopia
112. Recurrent Chest Pain
113. Irregular Recurrent Fever
114. Fever, Headache and Photophobia
115. Recurrent Meningitis
116. Lupus, Macrophage Activation Syndrome, and Invasive Infections
117. Recurrent Edema
118. Recurrent, Non-Pitting Edema of Lips, Extremities, and Genitalia
119. Recurrent Abdominal Pain
120. Laryngeal Edema
121. Lips Angioedema after Dental Procedure
122. Chronic Diarrhea, Recurrent Edema and Respiratory Infections
123. Otitis Media and Gait Disturbance
124. Regression of Her Ability to Walk
125. Microcephaly and a History of Recurrent Respiratory Infections
126. Recurrent Respiratory Infections and Chronic Hepatic Disease
127. Family Members with Congenital Heart Disease and Hypogammaglobulinemia
128. Erythrodermic Rash and Seizures
129. Bloody Diarrhea
130. Leukocytoclastic Vasculitis
131. Progressive Renal Failure with Lymphopenia
132. Bloody Stool and Recurrent Infections
133. Idiopathic Thrombocytopenic Purpura
134. Allergy and Recalcitrant Wart
135. Recurrent Cutaneous and Sinopulmonary Infections
136. Cold Abscesses and Lymphadenopathy
137. Recurrent Pneumonia and Fracture in the Femur
138. Fractures Following Minimal Trauma
139. Cough and Dyspnea
140. Skin Abscesses, Eczema and Lymphopenia
141. Lymphopenia and Neutropenia
142. Red Peeling
143. BCGosis and Hyperferritinemia
144. Mycobacterial Infection, Ectodermal Dysplasia and Thrombocytopenic Purpura
145. Progressive Hypotonia with Lymphopenia
146. Painless Hematuria and Repaired Patent Ductus Arteriosus
147. Intractable Diarrhea and Failure to Thrive
148. Alopecia, Hypothyroidism, Leukopenia and Hypogammaglobulinemia

This book comprises a collection of categorized case-based questions, directed and meticulously selected to cover the most common and most important aspects of immunodeficiency diseases. Immunodeficiency disorders of infancy and childhood such as antibody deficiencies, phagocyte defects and defects in innate immunity are addressed among others. Each chapters starts with a brief of the initial presentation and lab data of the patient, followed by a series of 5-6 multiple choice questions (MCQs), leading the reader to the diagnosis and best of practice in a step-wise manner. This MCQ format along with precise, yet detailed answer ensures a quick, case-based, reality learning to the reader. This comprehensive MCQ series, is an essential reading material that a pediatric clinician, hematologist, immunologist, transplant specialist, or pulmonologist, can not afford to miss.

Features
• Presents cases based on real patients from referral centers all over the world
• Covers main areas of immunodeficiency diseases presenting over 160 cases
• Guides the reader through the different stages of clinical practice

Author
Nima Rezaei, is a MD, PhD in Clinical Immunology and Human Genetics. Having finished his PhD he was awarded a fellowship in Clinical Immunology and Bone Marrow Transplantation, Paediatric Immunology and Infectious Diseases in Northern Supra Regional Bone Marrow Transplant Unit for SCID and Related Disorders, Newcastle General Hospital. He has since authored more than 500 publications, including the Springer, "Primary Immunodeficiency Diseases", Immunology of Aging" and "Cancer Immunology" series, to which he was awarded the 10th, 16thand 17th Avicenna Award for the book of the year. He was recognized as the distinguished young researcher to the prestigious Rhazi Award in in Medical Science Research on 2006 and 2012. In 2017 he was recognized by the National Academy of Medical Sciences, as “Iran’s Best Medical Researcher of the Past Decade’’. Iranian Primary Immunodeficiency Diseases Registry (IPIDR) since 1999, having more than thousands of PID and Paediatric Allergology and Immunology registered, is indeed one of his great scientific legacies.