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110,66 €Vaccinology: An Essential Guide outlines in a clear, practical format the entire vaccine development process, from conceptualization and basic immunological principles through to clinical testing and licensing of vaccines. With an outstanding introduction to the history and practice of vaccinology, it also guides the reader through the basic science relating to host immune responses to pathogens.
Covering the safety, regulatory, ethical, and economic and geographical issues that drive vaccine development and trials, it also presents vaccine delivery strategies, novel vaccine platforms (including experimental vaccines and pathogens), antigen development and selection, vaccine modelling, and the development of vaccines against emerging pathogens and agents of bioterror. There are also sections devoted to veterinary vaccines and associated regulatory processes.
Vaccinology: An Essential Guide is a perfect tool for designed for undergraduate and graduate microbiologists and immunologists, as well as residents, fellows and trainees of infectious disease and vaccinology. It is also suitable for all those involved in designing and conducting clinical vaccine trials, and is the ideal companion to the larger reference book Vaccinology: Principles and Practice.
Table of Contents
Contributors vii
Preface ix
1 The history of vaccine development and the diseases vaccines prevent 1
2 The vaccine development pathway 33
3 Control and eradication of human and animal diseases by vaccination 43
4 Pathogenesis of infectious diseases and mechanisms of immunity 59
5 The host immune response protective immunity and correlates of protection 73
6 Adjuvants: making vaccines immunogenic 93
7 Discovery and the basic science phase of vaccine development 109
8 Microbial-based and material-based vaccine delivery systems 127
9 Licensed vaccines for humans 152
10 Veterinary vaccines 181
11 Development of vaccines for microbial diseases 192
12 The regulatory path to vaccine licensure 212
13 Veterinary vaccines: regulations and impact on emerging infectious diseases 232
14 Vaccine manufacturing 243
15 Clinical evaluation of vaccines 260
16 Vaccine recommendations and special populations 273
17 Vaccine safety 287
18 Understanding and measuring the dynamics of infectious disease transmission 304
19 Vaccines from a global perspective 319
20 Political ethical social and psychological aspects of vaccinology 335
Index 358
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