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91,84 ۥ SECTION I: THRESHOLDS OF GENOTOXIC CARCINOGENS
1. Low dose effects of chemical carcinogens
2. Cancer risk at ultra low dose
3. Non-linearity of tumor induction at low doses
4. Low dose effects of radiation and chemicals
• SECTION II: MECHANISMS OF GENOTOXIC THRESHOLDS
5. Role of translesion DNA synthesis in chemical mutagenesis and the thresholds
6. Thresholds of alkylating carcinogens including the case of Viracept
7. Role of DNA repair in oxidative carcinogenesis and the implication in thresholds
8. Thresholds for genotoxicity in germ cells
9. DNA damage induced by endogenous insult
• SECTION III: REGULATION OF LOW DOSE GENOTOXIC CARCINOGENS
10. Threshold of toxicological concern in pharmaceutical contaminants
11. Approach to threshold issues by ILSI
12. Consensus of IWGT for genotoxic thresholds
13. Practical thresholds in occupational exposure limits for carcinogens
14. Statistical analysis of genotoxic thresholds
• SECTION IV: INTERACTION OF GENOTOXIC CARCINOGENS IN COMPLEX ENVIRONMENTAL MIXTURES
15. Thresholds for genotoxicity of air pollutants
16. Phase II detoxication and the contribution to genotoxic thresholds
17. Thresholds in environmental carcinogens
• SECTION V: LOW-LEVEL EXPOSURE OF GENOTOXIC CARCINOGENS AND FOOD SAFETY
18. Safe doses of genotoxic compounds in food
19. Risk communication about genotoxic thresholds
Features:
• Unites an international team of experts to provide a balanced overview of the current opinion on thresholds of genotoxic carcinogens
• Provides all the information readers need to determine a safe threshold for potential genotoxic carcinogens
• Includes information on the mechanisms of genotoxic carcinogens and how these can inform regulation
• Serves as an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation
Authors
• Takehiko Nohmi, PhD, Visiting Scientist, Scientist Emeritus, Biological Safety Research Center, National Institute of Health Sciences, Japan; Science Coordinator, Japan Agency for Medical Research and Development, Japan.
• Shoji Fukushima, Japan Bioassay Research Center, Japan
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