TARGETED THERAPY IN TRANSLATIONAL CANCER RESEARCH

Targeted Therapy in Translational Cancer Research for the Translational Oncology series provides a comprehensive overview of recent developments in our understanding of tumor biology, elucidates the roles of targets and pathways involved in carcinogenesis, and describes current state-of-the-art anticancer therapy, as well as the most promising areas of translational research and targeted therapy.
• Introduces cutting-edge ‘bench to bedside and back’ breakthroughs which have transformed the diagnosis, prognosis, and treatment of cancer
• Covers basic principles of targeted therapy, including immunotherapy and the roles of cancer stem cells, the microenvironment, angiogenesis, epigenetics, microRNAs, and functional imaging in precision medicine
• Summarises major advances in therapeutic management of hematologic malignancies and solid tumors using conventional therapy, targeted therapy, immunotherapy, or novel treatment modalities

Author Information
• Apostolia-Maria Tsimberidou, MD PhD. Department of Investigational Cancer Therapeutics. The University of Texas MD Anderson. Cancer Center. Houston, TX, USA.
• Razelle Kurzrock. Center for Personalized Cancer Therapy, UC San Diego - Moores Cancer Center. La Jolla, CA, USA.
• Kenneth C. Anderson MD. LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical. Oncology, Dana Farber Cancer Institute, Harvard Medical School. Boston, MA, USA.

Contents
Part I Principles of Targeted Therapies
1 Toward Personalized Therapy for Cancer, 3
2 Combining Targeted Therapies, 14
3 Principles of Targeted Immunotherapy, 27
4 Cancer Stem Cell Principles, 39
5 The Tumor Microenvironment as a Target for Therapeutic Intervention, 47
6 The Role of Angiogenesis in Cancer, 64
7 Epigenetics and Epigenetic Therapy of Cancer, 72
8 The Role of microRNAs in Cancer, 80
9 AcuteMyeloidLeukemia, 89
10 Targeted and Functional Imaging, 101
Part II Targeted Therapy in Hematological Malignancies
11 Targeted Therapies in Chronic Myeloid Leukemia, 113
12 Targeted Therapy for Acute Lymphoblastic Leukemia, 121
13 Chronic Lymphocytic Leukemia, 130
14 Multiple Myeloma, 145
15 The Impact of Genomics on Targeted Therapy in Multiple Myeloma and Lymphomas, 157
16 Targeted Therapy in Myelodysplastic Syndromes, 162
17 Lymphoma and Targeted Therapies, 169
Part III Targeted Therapy in Solid Tumors
18 Targeted Therapy in Solid Tumors: Brain, 179
19 Targeted Therapy for Breast Cancer, 190
20 Targeted Therapy in Solid Tumors: Colorectal Cancer, 193
21 Endometrial Cancer, 205
22 Targeted Therapy in Solid Tumors: Head and Neck, 216
23 Targeted Therapy in Solid Tumors: Lung Cancer, 224
24 Targeted Therapy in Melanoma, 231
25 Ovarian Cancer, 240
26 Molecular Therapeutics: Pancreatic Cancer, 255
27 Targeted Therapies for Pediatric Solid Tumors, 263
28 Prostate Cancer, 273
29 Renal Cell Carcinoma and Targeted Therapy, 287
30 Targeted Therapy in Solid Tumors: Sarcomas, 296
Part IV Targeted Therapy for Specific Molecular Aberrations
31 RAS-RAF-MEK Pathway: Aberrations and Therapeutic Possibilities, 305
32 The Phosphatidylinositol 3-Kinase Pathway in Human Malignancies, 315
33 Current Status and Future Direction of PARP Inhibition in Cancer Therapy, 325
34 Targeting the c-Met Kinase, 341
35 KIT Kinase, 347
36 TP53, 353
Part V Future Perspectives
37 Future Perspectives, 363
Index, 371