RECURRENT PREGNANCY LOSS. CAUSES, CONTROVERSIES AND TREATMENT. 4TH EDITION

• The Epidemiology of Recurrent Pregnancy Loss
Ole B. Christiansen
• The Signaling Between Embryo and Mother as a Basis for the Development of Tolerance
Eytan R. Barnea
• Recurrent Pregnancy Loss: From Evidence Based to Personalised Medicine
Howard J. A. Carp
• Collection of Data and Role of Artificial Intelligence
Abraham Tsur and Oren Barak
• The Genetics of Recurrent Pregnancy Loss
Anat Grossman-Jonish
• Epigenetic Regulation in RPL
Howard Carp and Dov Feldberg
• The Endometrial Factor in Recurrent Pregnancy Loss
Ka Ying Bonnie Ng and Ying Cheong
• Fetal Structural Malformations and Recurrent Pregnancy Loss
Howard J. A. Carp, Thomas Philipp, Micha Baum, and Michal Berkenstadt
• The Endocrinology of Recurrent Pregnancy Loss
Pluchino Nicola, Hounga Ayadjenou, and Andrea Riccardo Genazzani
• The Etiology of the Antiphospholipid Syndrome
Cristina Garufi, Giuliana Beneduce, Francesca Rizzo, Ester Garufi, Yehuda Shoenfeld, and Sara De Carolis
• Defects in Coagulation Factors Leading to Recurrent Pregnancy Loss
Aida Inbal and Howard Carp
• The Immunobiology of Recurrent Miscarriage
Marighoula Varla-Leftherioti, Theodora Keramitsoglou, Barbara Geladakis, and Christina Tsekoura
• Uterine Anomalies and Recurrent Pregnancy Loss
Roy Mashiach, Daniel S. Seidman, and Mordechai Goldenberg
• The Male Factor in Recurrent Pregnancy Loss
Catherine F. Ingram, Nannan Thirumavalavan, Marc Goldstein, and Dolores J. Lamb
• Infection and the Microbiome Leading to Pregnancy Loss
Mayumi Sugiura-Ogasawara, Hiroyuki Yoshihara, Shinobu Goto, and Tamao Kitaori
• Inflammatory Placental Disorders and RPL
Keren Ofir and Denise Dana Frank
• Ultrasound Follow Up in Early Pregnancy
Akhila Vasudeva and Pratap Kumar
• Biochemical Pregnancies
Howard J. A. Carp and Daniel S. Seidman
• Threatened Miscarriage and Recurrent Pregnancy Loss
Howard J. A. Carp
• The Role of Cerclage and Pessaries
Abraham Tsur, Howard J. A. Carp, and Israel Hendler
• What Genetic Screening is Appropriate in Recurrent Pregnancy Loss?
Peter Benn and Howard J. A. Carp
• Obstetric Outcomes After Recurrent Pregnancy Loss
Rakefet Yoeli Ulman, Howard J. A. Carp, and Shali Mazaki-Tovi
• Investigation Protocol for Recurrent Pregnancy Loss
Howard J. A. Carp
• Should Progestogen Supplementation Be Used in Recurrent Pregnancy Loss? Yes
Pedro Melo and Arri Coomarasamy
• Should Progestogen Supplementation Be Used in Recurrent Pregnancy Loss? No
Abdullatif Elfituri, Stergios K. Doumouchtsis, Mudiaga Eseajeberuo Zini, Ramesh Ganapathy, and Hassan Shehata
• hCG Supplementation in Recurrent Pregnancy Loss
Carlo Ticconi and C. V. Rao
• Antiphospholipid Syndrome: Management of the Obstetric Patient
Ashley E. Benson and D. Ware Branch
• Can Recurrent Pregnancy Loss Be Prevented by Empirical Antithrombotic Agents? Yes
Michael Kupferminc
• Can Recurrent Pregnancy Loss Be Prevented by Empirical Antithrombotic Agents? No
Pelle Lindqvist
• Empirical In Vitro Fertilization for Recurrent Pregnancy Loss: Is It a Valid Concept?
Michal Kirshenbaum and Raoul Orvieto
• Should PGT-A Be Performed in Recurrent Pregnancy Loss? Yes
Karissa C. Hammer and Ilan Tur-Kaspa
• Should PGT-A Be Performed in Recurrent Pregnancy Loss? No
Raoul Orvieto and Norbert Gleicher
• Third Party Reproduction in Recurrent Pregnancy Loss
Gautam Nand Allahbadia, Akanksha Allahbadia, and Swati Gautam Allahbadia
• Paternal Leucocyte Immunization for Recurrent Pregnancy Loss: The Current Situation
Amin Gorgy and Conor Harrity
• IVIg Treatment for Recurrent Pregnancy Loss: Yes
Genevieve Genest, Martine Boivin, Shorooq Banjar, Alyssa Hochberg, Rabea Yousef Khoudja, William Buckett, and Carl Laskin
• Hydroxychloroquine for RPL
Shiri Weinstein and Nancy Agmon-Levin
• Should Filgrastim Be Used? Yes
Fabio Scarpellini and Marco Sbracia
• Should Filgrastim Be Used? No
Abey Eapen
• Chinese Medicine in RPL
Aviv Messinger and Keren Sela
• Decline in Sperm Quality
Dov Feldberg and Howard J. A. Carp

This edition, like the previous editions of this successful text, tries to summarize the controversies and discuss the scientific basis for various causes of recurrent pregnancy loss in depth and to clarify the various treatment modalities. Much of the controversy that previously seemed to have been settled in many areas of recurrent pregnancy loss has now returned again, particularly regarding the use of progestogens, PGT-A, filgrastim, and anticoagulants, giving this new edition new relevance. Also included here are the continuing advances in genetics and immunomodulation; and the text includes discussion of the roles of evidence-based medicine and personalized medicine and the treatment of the resistant patient.

Both general gynaecologists and specialists in recurrent pregnancy loss will find this a helpful reference for their approach to patients.

From reviews of previous editions:

“A leading team … successfully reviews the controversies surrounding each topic… Essential reading for any physician counseling or treating women with recurrent pregnancy loss.” (European Gynecology & Obstetrics)

“Needed, logically organized, and balanced… a welcome reference.” (Fertility & Sterility)