RECURRENT PREGNANCY LOSS: CAUSES, CONTROVERSIES, AND TREATMENT. 2ND EDITION

The Epidemiology of Recurrent Pregnancy Loss.
Signaling between Embryo and Mother in Early Pregnancy: Basis for Development of Tolerance.
Genetics of Spontaneous Abortions.
Debate: Should Fetal Karyotyping be Performed in Recurrent Pregnancy Loss? Yes.
Debate: Should Fetal Karyotyping be Performed in Recurrent Pregnancy Loss? No.
Debate: Should Preimplantation Genetic Screening be Performed in Recurrent Pregnancy Loss? Yes.
Debate: Should Preimplantation Genetic Screening or Preimplantation Genetic Diagnosis be Performed in Recurrent Pregnancy Loss? No.
Debate: Screening for Chromosomal Aberrations in Recurrent Pregnancy Loss: Nonspecific Testing is Sufficient.
Debate: Screening for Chromosomal Aberrations in Recurrent Pregnancy Loss: Noninvasive Prenatal Testing, Cytogenetics and Ultrasound are Needed.
Does the Maternal Immune System Regulate the Embryo’s Response to External Toxins?.
Fetal Structural Malformations—Embryoscopy.
Fetal Structural Malformations—Ultrasound.
Endocrinology of Pregnancy Loss.
Debate: Should Progesterone Supplements be Used? Yes.
Debate: Should Progesterone Supplements be Used? No.
Opinion: Progestogens in Recurrent Miscarriage.
Debate: Should Human Chorionic Gonadotropin Supplementation be Used? Yes.
Debate: Should Human Chorionic Gonadotropin Supplementation be Used? No.
Antiphospholipid Syndrome—Pathophysiology.
Diagnosis of Antiphospholipid Antibody-Associated Abortions.
Management of Antiphospholipid Syndrome in Pregnancy.
Defects in Coagulation Factors Leading to Recurrent Pregnancy Loss.
Debate: Should Thromboprophylaxis be Used in Hereditary Thrombophilias with Recurrent Pregnancy Loss? Yes.
Debate: Should Thromboprophylaxis be Used in Hereditary Thrombophilias with Recurrent Pregnancy Loss? No.
Opinion: Can Recurrent Pregnancy Loss be Prevented by Antithrombotic Agents?.
Uterine Anomalies and Recurrent Pregnancy Loss.
The Immunobiology of Recurrent Miscarriage.
Debate: Should Immunotherapy be Used? Lymphocyte Immunization Therapy: Yes.
Debate: Should Immunotherapy be Used? Intravenous Immunoglobulin: Yes.
Debate: Should Immunotherapy be Used? Granulocyte colony stimulating factor: Yes.
Debate: Should Immunotherapy be Used? No.
Autoimmunity and Recurrent Pregnancy Loss.
Infections and Recurrent Pregnancy Loss.
The Male Factor in Recurrent Pregnancy Loss and Embryo Implantation Failure.
Midtrimester Loss: The Role of Cerclage and Pessaries.
Midtrimester Loss and Viability.
Obstetric Outcomes after Recurrent Miscarriage.
Coping with Repeated Pregnancy Loss: Psychological Mechanisms.
Methodological Issues in Evidence-Based Evaluation of Treatment for Recurrent Miscarriage.
Investigation Protocol for Recurrent Pregnancy Loss.
A New Algorithm for Evaluation and Treatment of Recurrent Pregnancy Loss.
Third Party Reproduction in Recurrent Pregnancy Loss.
"Slippery Fetus": Recurrent Pregnancy Loss in Traditional Chinese Medicine.
A Patient’s Perspective.
Epilogue
Index

• Provides the insight of international contributors with a wide range of experience
• Explores the methodology of clinical research and the application of evidence-based medicine to clinical practice
• Features new material on the latest controversies and debates
• Includes new chapters on autoimmunity, third party reproduction, the use of immunostimulants such as CSF, and Chinese medicine

Recurrent pregnancy loss presents a vexing clinical problem primarily for medical professionals treating patients in reproductive medicine and in maternal-fetal medicine. However, with its numerous causes and various suggested treatment options, the problem is more multidisciplinary in nature, involving gynecology, genetics, endocrinology, immunology, pediatrics, and internal medicine. Exploring basic science and clinical applications, the second edition of the bestselling textRecurrent Pregnancy Loss: Causes, Controversies, and Treatment provides an authoritative and comprehensive update on advances in the understanding and management of this troubling phenomenon.
The book covers basic scientific topics such as genetics and cytokines and profiles major advances in immunology, endocrinology, and thrombotic mechanism. It discusses the methodology of clinical research and the application of evidence-based medicine to clinical practice. It also reviews various late obstetric complications, along with issues caused by extreme prematurity and possible resulting handicaps. This second edition presents new material on the latest controversies, featuring opinions from both sides of ongoing debates. It includes new chapters on autoimmunity, third party reproduction, the use of immunostimulants such as CSF, and Chinese medicine.
Designed for specialists working in reproductive medicine clinics and those involved with maternal-fetal care, the book is also ideal for generalists and gynaecologists seeking a comprehensive view of developments in the field.

Author
Prof. Carp studied Medicine at Charing Cross Hospital Medical School in London. He completed his training for the MRCOG in the UK. He has since worked at the Sheba Medical Center, Tel Hashomer, in Israel, and has held a Senior Lecturer post in Embryology at Tel Aviv University. He is Professor of Obstetrics and Gynaecology at Tel Aviv University. He has many clinical interests, including ectopic pregnancy, implantation, and infertility. He has edited two other books: The Infertility Manualand Principles and Practice of Assisted Reproductive Technology. Another book,Progestogens in Gynecological Practice is in press. He has published over 70 original research articles, 16 review articles and 6 chapters in books and has been invited to lecture in many parts of the world. Prof. Carp has taken a special interest in recurrent miscarriage, other forms of pregnancy loss, and infertility in general.