QUASISPECIES. FROM THEORY TO EXPERIMENTAL SYSTEMS

1. What Is a Quasispecies? Historical Origins and Current Scope
2. The Nucleation of Semantic Information in Prebiotic Matter
3. Evolution of RNA-Based Networks
4. Quasispecies on Fitness Landscapes
5. Mathematical Models of Quasi-Species Theory and Exact Results for the Dynamics
6. Theoretical Models of Generalized Quasispecies
7. Theories of Lethal Mutagenesis: From Error Catastrophe to Lethal Defection
8. Estimating Fitness of Viral Quasispecies from Next-Generation Sequencing Data
9. Getting to Know Viral Evolutionary Strategies: Towards the Next Generation of Quasispecies Models
10. Cooperative Interaction Within RNA Virus Mutant Spectra
11. Arenavirus Quasispecies and Their Biological Implications
12. Models of Viral Population Dynamics
13. Fidelity Variants and RNA Quasispecies
14. Antiviral Strategies Based on Lethal Mutagenesis and Error Threshold

This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology.

Key Features
• Covers theoretical and experimental aspects of quasispecies
• Includes the most recent developments in quasispecies research
• Provides in-depth coverage of cutting-edge research in theory and experiment

Authors
• Esteban Domingo is a professor at the Spanish Research Council at Centro de Biología Molecular Severo Ochoa (Madrid) and President of the Spanish Society of Virology. He is a member of EMBO and Real Academía de Ciencias Exactas, Físicas y Naturales.
• Peter Schuster, em. professor of University of Vienna is a member of Leopoldina, Nationale Akademie der Wissenschaften, National Academy of Sciences USA, European Academy of Sciences and Arts and several other institutions. He worked together with Manfred Eigen and developed together with him the concepts of "quasispecies" and "hypercycles".