PRACTICAL HANDBOOK OF OCT ANGIOGRAPHY

1. Principles of Optical Coherence Tomography Angiography 1
David Huang, Yali Jia, Simon S Gao
• Optical Coherence Tomography Angiography 1
2. Interpretation of Optical Coherence Tomography Angiography 6
David Huang, Yali Jia, Simon S Gao
• Anatomic Reference Planes and Angiographic Slabs 6
• AngioVue Default Segmentation and Display 8
3A. Quantification of Vascular Layers with Optical Coherence
Tomography Angiography 16
Marco Rispoli
• Flow Area 16
• Nonflow Area (Vascular Dropout Area) 16
• Flow Density Map 16
3B. Practical Problems and Artifacts in Optical Coherence Tomography Angiography 22
Marco Rispoli, Bruno Lumbroso
4. Optical Coherence Tomography Angiography of Normal Retina and
its Vascular Structure 24
Maria Cristina Savastano, Marco Rispoli, Bruno Lumbroso
• Retinal Vascular Networks 24
5. Diabetic Retinopathy and Optical Coherence Tomography Angiography 28
Maria Cristina Savastano, Marco Rispoli, Bruno Lumbroso
• Objective Quantitative Analysis 32
6. Vascular Occlusions 33
Marco Rispoli, Bruno Lumbroso, Maria Cristina Savastano,
Jean Francois Le Rouic, Pascal Peronnet
Branch or Central Vein Occlusions 33
Marco Rispoli, Bruno Lumbroso, Maria Cristina Savastano
• Central Retinal Vein Occlusion and Venous Branch Occlusion 33
• Optical Coherence Tomography Angiography 34
Retinal Artery Occlusion 40
Jean Francois Le Rouic, Pascal Peronnet
• Retinal Artery Occlusion: Acute Stage 40
• Retinal Artery Occlusion: Late Phase 41
• Treatment 42
7. Type 1, Type 2 and Type 4 (Mixed) Choroidal Neovascularization 44
Bruno Lumbroso, Marco Rispoli
• Assessing New Vessels 45
• Type 1 New Vessels 45
• Type 2 New Vessels 47
• Type 3 New Vessels 50
• Type 4 New Vessels (Mixed Type) 50
• Neovascular Membranes in Myopia 52
8. Type 3 Neovascularization Features on Optical Coherence
Tomography Angiography 56
Alexandra Miere, Giuseppe Querques, Ala El Ameen, Vittorio Capuano,
Oudy Semoun, Eric Souied
9. Choroidal Neovascularization in Diseases other than
Age-related Macular Degeneration 61
Adil El Maftouhi, Maddalena Quaranta-El Maftouhi
Degenerative Myopia, CSC, Multiple Choroiditis 61
Adil El Maftouhi, Maddalena Quaranta-El Maftouhi
• Degenerative Myopia 61
• Choroidal New Vessel Complications in Angioid Streaks 61
• Chronic Central Serous Chorioretinopathy 61
• Choroidal New Vessel Complications in Multifocal Choroiditis 62
Polypoidal Choroidal Vasculopathy 77
Maddalena Quaranta-El Maftouhi, Adil El Maftouhi
10. Other Types of Choroidal Neovascularization not Linked to
Age-related Macular Degeneration 87
Leonardo Mastropasqua, Luca Di Antonio
11. Subretinal Fibrosis Features in Optical Coherence Tomography Angiography 93
Eric Souied, Alexandra Miere, Oudy Semoun, Eliana Costanzo, Salomon Yves Cohen
12. Evolution in Time of Flows after Treatment 98
Bruno Lumbroso, Marco Rispoli
• Early Changes after Treatment 98
13. Optic Nerve and Glaucoma 103
Michel Puech
• Optical Coherence Tomography Angiography around the Optic Disc 103
• Vascularization Inside the Optic Disc 104
14. Comparing Fluorescein Angiography with Optical
Coherence Tomography Angiography 107
Bruno Lumbroso, Marco Rispoli
• Fluorescein Angiography 107
Index 115

This book is a practical guide to the revolutionary technique of non-invasive, dyeless OCT angiography imaging. This new diagnostic tool complements, and in part replaces, fluorescein angiography.
Beginning with an introduction to the principles and interpretation of OCT angiography, the book covers operating principles, recent advances, the future of OCT, and diagnosis of vascular retinopathies.
The book describes how this new technology is used to study inner and outer retina disorders, both qualitatively and quantitatively, and to classify choroidal neovascularisation (CNV) in a non-invasive manner, highlighting morphology, flow and depth. It also provides new technical and clinical information on the study of glaucoma.
Presented in a step by step format, the book is highly illustrated with images obtained from Optovue’s Avanti Widefield OCT hardware platform and Angiovue OCT angiography software.

Key Points
• Practical guide to revolutionary technique of non-invasive, dyeless OCT angiography imaging
• Covers principles and interpretation, operating principles, recent advances, future of OCT and diagnosis of vascular retinopathies
• All images obtained from Optovue’s Avanti Widefield OCT hardware platform and Angiovue OCT angiography software
• Highly experienced, well-recognised author team led by Prof Bruno Lumbroso

Author information
• Bruno Lumbroso MD. Director, Centro Italiano Macula, Rome, Italy
• David Huang MD PhD. Peterson Professor of Ophthalmology, Professor, Biomedical Engineering, Casey Eye Institute, Oregon Health and Science University, Portland, USA
• Eric Souied MD PhD. Professor and Head, Centre Hospitalier Intercommunal de Creteil and Henri Mondor Hospital, Paris, France
• Marco Rispoli MD. Staff Ophthalmologist, Department of Ophthalmology, Ospedale Nuova Regina Margherita, Centro Italiano Macula, Rome, Italy