OSTEOSARCOMA. A MULTIDISCIPLINARY APPROACH TO TREATMENT

1. Genetics of Osteosarcoma
2. Basic Research for Osteosarcoma Lung Metastasis (LM8)
3. Immunotherapy for Osteosarcoma
4. Outcome of Treatment for Osteosarcoma of the Extremities Over the Last 20 Years: Report from 11 Referral Centers in Japan
5. Osteosarcoma in the Elderly: Clinical Features and Outcome
6. Prognostic Factors for Osteosarcoma Patients
7. Neoadjuvant Chemotherapy Developed in Japan
8. Neoadjuvant Chemotherapy: Osaka University Osteosarcoma (OOS) Regimen
9. Endoprosthetic Reconstruction for Extremity Osteosarcoma
10. Limb-Salvage Surgery and Reconstruction for Skeletally Immature Childhood Osteosarcoma: Extendible Endoprosthesis
11. Limb Salvage Surgery for Pelvic Osteosarcoma
12. Management of Postoperative Infection After Limb Salvage Surgery in Osteosarcoma Patients
13. Biological Reconstruction for Extremity Osteosarcoma: Long-Term Results and Current Concept of Intraoperative Extracorporeal Irradiated Bone Graft (IORBG)
14. Biological Reconstruction for Extremity Osteosarcoma: Pasteurized Autogenous Bone Graft
15. Biological Reconstruction for Extremity Osteosarcoma: Liquid Nitrogen-Treated Tumor-Bearing Bone Graft
16. Biological Reconstruction for Extremity Osteosarcoma: Distraction Osteogenesis Technique
17. Limb-Saving Surgery Using In Situ Preparation (ISP) Method
18. Carbon Ion Radiotherapy for Unresectable Osteosarcoma of the Trunk
19. Treatment of Osteosarcoma Patients with Pulmonary Metastasis
20. Long-Term Outcomes and Quality of Life (QOL) in Survivors of Pediatric and Adolescent Osteosarcoma

This book reviews the brilliant progress made in the past three decades in clinical outcomes for osteosarcoma patients treated with a multidisciplinary approach, including limb-salvage surgery combined with neoadjuvant multidrug chemotherapy and aggressive management of pulmonary metastasis. Osteosarcoma was a miserable disease for adolescents and young adults until the early 1970s, with a survival rate that was less than 10–15% even after amputation for affected limbs because of the progression of pulmonary metastasis. With the development of neoadjuvant chemotherapy for osteosarcoma, including high-dose methotrexate, doxorubicin, cisplatin, and ifosfamide during the late 1970s and the 1980s, however, the prognosis has dramatically improved. Limb-salvage surgery for patients with extremity osteosarcoma is now a gold-standard surgical procedure for more than 90% of patients with localized disease. Additionally, aggressive pulmonary metastasectomy for patients with lung metastasis from osteosarcoma has contributed to improvement of their survival. More recently, carbon-ion radiotherapy has also been introduced for patients with unresectable osteosarcoma of the trunk, as in the spine and pelvis. In this volume the author provides valuable descriptions of an important new treatment modality for a multidisciplinary approach for osteosarcoma patients.

Features
• Provides valuable descriptions of an important new treatment for osteosarcoma
• Reviews the outstanding advances made in clinical outcomes for osteosarcoma over the past three decades
• Presents a multidisciplinary approach, including surgery with neoadjuvant chemotherapy

Authors
• Takafumi Ueda, Osaka National Hospital, Orthopaedic Oncology Group, Department of Orthopaedic Surgery
• Akira Kawai, National Cancer Center Hospital, Division of Musculoskeletal Oncology