NEUROPATHOLOGY OF AGING AND ALZHEIMER’S DISEASE

• Part I: Alzheimer and his contemporaries
1. Alzheimer’s disease: a fortuitous beginning
2. Alzheimer’s first case
3. Alzheimer’s second case and the naming of Alzheimer’s disease
4. Some early observations of Alzheimer’s contemporaries
5. Early studies on senile dementia and aging
6. The human element
References 000
• Part II: The dark ages
7. The 1920s and 1930s
8. The 1940s to the 1960s
• Part III: Beyond plaques and tangles: lewy bodies, vascular disease, and the rise of the acronyms
9. Lewy bodies
10. The role of vascular disease in Alzheimer’s disease neuropathology Atherosclerosis
11. The rise of the acronym References
12. Aging-related neuronal tau
13. Aging and disease-related astrocytic tau
14. TDP-43 in aging and Alzheimer’s disease
15. Argyrophilic grain disease
• Part IV: Alzheimer’s disease, dementia pugilistica, and the influence of neuropathology
16. Introduction to the traumatic brain injury--neurodegenerative disease dichotomy
17. Punch drunk syndrome: the first 30 years
18. Clinicopathological analysis from the 1950s and 1960s
19. 1970 to 2000: transitioning to an immunohistochemistry--only diagnosis
20. The modern chronic traumatic encephalopathy era
21. Postmortem of punch drunk boxers and chronic traumatic encephalopathy
• Part V: Familial alzheimer’s disease, down syndrome, and the amyloid cascade hypothesis
22. Familial Alzheimer’s disease and Down syndrome
23. The amyloid cascade hypothesis
• Part VI: Practical considerations in the diagnosis of alzheimer’s disease and aging
24. Application of consensus criteria
25. The diagnostic process

Neuropathology of Aging and Alzheimer’s Disease takes a foundational approach to the topic by offering basic scientific information and the latest advancements in the field. The focus of this reference is on neuropathology and recent advances in tissue characterization in aging, and in Alzheimer’s Disease. Neuropathology has direct relevance to therapeutic constructs and allows for an in-depth understanding of disease pathogenesis. It is a synthesis of the salient issues with respect to pathology, pathogenesis, diagnosis, disease, normal aging, biomarker relevance, and prospects for therapeutic intervention.

Features:
• Detailed discussion and analysis of early Alzheimer’s disease investigators and their findings
• Detailed discussion and analysis of the often-overlooked literature from the 1920’s to the 1960’s
• Detailed discussion and analysis of aging-related phenomena currently under study
• Detailed discussion and analysis of punch-drunk syndrome and the transition to modern understanding of chronic traumatic encephalopathy
• Detailed discussion and analysis of the pathology of autosomal dominant Alzheimer’s disease and Alzheimer’s disease associated with Down syndrome
• Practical issues with diagnosing and reporting Alzheimer’s disease and aging-related changes

Author
Rudy J. Castellani, Northwestern University Feinberg School of Medicine Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Chicago, USA.