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138,32 €As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail.
Table of contents (11 chapters)
1.Prologue
2.Introduction
3.Basic Organization of Non-thalamic Nuclei with Diffuse Cortical Projections
4.Microtubules and the Protein Tau
5.Early Presymptomatic Stages
6.Basic Organization of Territories That Become Sequentially Involved After Initial Involvement of Brainstem Nuclei with Diffuse Projections
7.The Pattern of Cortical Lesions in Preclinical Stages
8.Alzheimer-Associated Pathology in the Extracellular Space
9.The Pattern of Lesions During the Transition to the Symptomatic Phase and in Fully Developed Alzheimer’s Disease
10.Final Considerations
11.Technical Addendum
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