Descuento:
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Despues:
138,32 €1. Understanding the Complex Circuitry of lncRNAs at the X-inactivation Center and Its Implications in Disease Conditions
2. Long Non-coding RNA
3. Form and Function of Exosome-Associated Long Non-coding RNAs in Cancer
4. Long Noncoding RNAs in Lung Cancer
5. Pseudogene-Expressed RNAs: Emerging Roles in Gene Regulation and Disease
6. Functional Long Non-coding RNAs in Vascular Smooth Muscle Cells
7. Long Noncoding RNAs as Targets and Regulators of Nuclear Receptors
8. Noncoding Transcriptional Landscape in Human Aging
9. lncRNAs in Stress Response
10. Expression Specificity of Disease-Associated lncRNAs: Toward Personalized Medicine
This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.
Features
• Summarizes the tremendous progress made within the last decade in understanding the roles of lncRNA in human disease
• Bridges the divide between inferring lncRNA mechanisms and targeting lncRNAs by means of rational therapeutics
• Stresses the vital role of lncRNA disease mechanisms for a necessary and profound reassessment of Genome-Wide Association studies in the new era of personalized medicine
Author
Kevin Morris is an Associate Professor at the Department of Molecular and Experimental Medicine, The Scripps Research Institute in La Jolla, CA, USA. The responsible series editor is Peter K. Vogt, The Scripps Research Institute in La Jolla, CA, USA.
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