CARDIOVASCULAR CALCIFICATION AND BONE MINERALIZATION

1. The History of Cardiovascular Calcification
2. Basic Pathology of Arterial and Valvular Calcification in Humans
3. Developmental Pathways and Aortic Valve Calcification
4. Differential Mechanisms of Arterial and Valvular Calcification
5. Calcifying Extracellular Vesicles: Biology, Characterization, and Mineral Formation
6. Role of Biomechanical Stress and Mechanosensitive miRNAs in Calcific Aortic Valve Disease
7. The Role of Chronic Kidney Disease in Ectopic Calcification
8. The Role of Calcification in Peripheral Artery Disease
9. Bioprosthetic Heart Valve Calcification: Clinicopathologic Correlations, Mechanisms, and Prevention
10. Electron Microscopy for the Characterization of Soft Tissue Mineralization
11. Cardiovascular Calcification in Hutchinson-Gilford Progeria and Correlation with Age-Related Degenerative Calcification
12. Calcinosis in Scleroderma
13. Placental Calcification: Long-standing Questions and New Biomedical Research Directions
14. Heterotopic Ossification Following Traumatic Blast Injury
15. The Paradoxical Relationship Between Skeletal and Cardiovascular Mineralization
16. Cellular Contributors to Bone Homeostasis
17. Bone Biology, Modeling, Remodeling, and Mineralization
18. Osteoclasts in Cardiovascular Calcification
19. Imaging Cardiovascular Calcification Activity with 18F-Fluoride PET
20. The Role of Elastin Degradation in Vascular Calcification: Possibilities to Repair Elastin and Reverse Calcification
21. Clinical Trials and Calcification-Based Treatment Decisions
22. Surgical Versus Transcatheter Aortic Valve Replacement
23. Target Discovery in Calcification Through Omics and Systems Approaches

The book covers the basic science and clinical aspects of cardiovascular calcification and bone mineralization. Cardiovascular calcification is the leading predictor of cardiovascular morbidity and mortality, with a predictive value more significant than blood lipid levels. The presence of calcific mineral in cardiovascular tissues alters biomechanical performance, increasing workload on the heart and potentiating atherosclerotic plaque rupture and subsequent heart attack and stroke. This book examines the role of calcification in cardiovascular disease covering topics such as calcification in the atherosclerotic plaques and aortic valves arteries and valves, aortic valve replacement, peripheral artery disease, imaging of early calcification and target discovery. In addition, various forms of ectopic calcification as well as mechanisms of bone mineralization are discussed.
Cardiovascular Calcification and Bone Mineralization is an essential resource for clinicians, researchers, and other medical professionals in cardiology, pathology, and biomedical engineering.

Features
• Discusses treatments in bone disorders and ongoing therapeutic efforts in cardiovascular calcification
• Provides clinical strategies that may be applicable to many types of cardiovascular diseases
• Examines the physiological and pathological processes of cardiovascular and ectopic calcification as well as bone mineralization
• Aggregates knowledge from across disparate calcification disciplines

Authors
• Elena Aikawa, MD, PhDDirector, Vascular Biology ProgramDirector, Heart Valve Translational Research Program (HVTRP)Brigham and Women’s HospitalAssociate Professor of MedicineHarvard Medical SchoolBoston, MA
• Joshua D. Hutcheson, PhDAssistant ProfessorBiomolecular Sciences InstituteDepartment of Biomedical EngineeringFlorida International UniversityMiami, FL