CANCER STEM CELLS

- Section I Essentials of Cancer Stem Cells and Conceptual Modeling 1
1 Theoretical and Experimental Foundations of the “Cancer Stem Cell” Model 3
2 The Hallmarks of Prostate Cancer Stem Cells 17
3 Self-Renewal, Induced Proliferation, and Autonomous Cell Growth Represent Distinct Modes of Cell Multiplication: Relevance to the Cancer Stem Cell Theory 39
4 Human Embryonic Stem Cells and Cancer: Modeling Disease in a Dish 49
5 Cancer Stem Cell as a Result of a Reprogramming-Like Mechanism: Implications in Tumor Development and Treatment 61
6 A Cancer Stem Cell Model: An Insight into the Conversion of Induced Pluripotent Stem Cells to Cancer Stem-Like Cells 79
7 Altruistic Stem Cells and Cancer Stem Cells 89
8 The Emerging Concept of EMT-Induced Cancer Stem Cells 107
9 Models to Study Chronic Myeloid Leukemia Cancer Stem Cells 119
10 Cancer Stem Cells in Melanoma: Biomarkers and Mathematical Models 133
- Section II Stem Cells in Liquid Tumors 143
11 Acute Myeloid Leukemia Stem Cells—Updates and Controversies 145
12 Leukemia-Initiating Cells in Acute Lymphoblastic Leukemia 161
- Section III Stem Cells in Solid Tumors 171
13 Lung Cancer Stem Cells and Resistance to Radiotherapy 173
14 Prostate Cancer Cell Heterogeneity and Prostate Cancer Stem Cells 183
15 Glioblastoma Stem Cells Drive Tumor Recurrence and Patient Relapse: What’s the Evidence? 193
16 Stem Cells and Pancreatic Cancer 209
17 Melanoma Subpopulations with Cancer Stem Cell Phenotypes 223
18 Sarcoma Stem Cells 235
- Section IV Cancer Stem Cells in Tumor Metastasis Perspective 247
19 Cancer Stem Cells in Metastasis and Minimal Residual Disease 249
20 Role of Cancer Stem Cells in Metastasis 259
21 Cancer Stem Cells and the Stromal Microenvironment 273
22 A Perspective on Breast Cancer Malignant Progression: From Cancer Stem Cell Intra Tumor Heterogeneity to Metastasis-Initiating Cells 287
- Section V Novel and Potential Targets in Cancer Stem Cells 295
23 Targeting Cancer Stem Cells—Modulating Embryonic Stem Cell Signaling, Epigenetics, and Tumor Metabolism 297
24 Oct4, Oct1, and Cancer Stem Cells 319
25 The Role of Cripto-1 in Cancer and Cancer Stem Cells 331
26 Leptin Signaling in the Regulation of Stem and Cancer Stem Cells 347
27 Tumor-Initiating Stem-Like Cells: Carcinogenesis through Toll-Like Receptors, Environmental Factors, and Virus 361
28 The Role of Epithelial Cell Polarity Pathways on Cancer Stem Cells 373
29 Cancer-Initiating Cells, Exosomes, and the Premetastatic Niche 389
30 MicroRNA Therapeutics to Target Brain Tumor Stem Cells 403
31 The Riboproteome Orchestrates Self-Renewal and Cell Fate in Leukemia 417
- Section VI Clinical Relevance of Cancer Stem Cells in Patients 435
32 Targeting Different States of Breast Cancer Stem Cells 437
33 Difficulties in Targeting the Beating Heart: Therapeutic Implications of the Cancer Stem Cell Hypothesis in Melanoma 451
34 Targeting Cancer Stem Cells for Overcoming Drug Resistance and Cancer Progression 461
35 The Role of Cancer Stem Cells in Tumor Radioresistance 473
Index 493

Cancer Stem Cells covers a wide range of topics in cancer stem cell biology, including the functional characteristics of cancer stem cells and how they're generated, where they are localized, the means by which cancer stem cells can be targeted, and how cancer stem cells can be reprogrammed back to normal tissue stem cells. Each chapter begins with a brief historical note and concept summary, followed by a description of the latest basic or clinical advance associated with the topic.
Cancer Stem Cells builds systematically from coverage of the basic research stage to an advanced research level, from clinical relevance to therapeutic potential, and will be a valuable resource for professionals in the fields of cancer research and stem cell biology.

Author Information
Dr. V.K. Rajasekhar, M.Sc., M.Phil., Ph.D., is a Senior Research Scientist at Memorial Sloan-Kettering Cancer Center, New York. His work with patient derived prostate cancer stem cell xenografts, a first study in renewable Biobanking of these clinically relevant cells, has garnered eclectic post-publication reviews. Dr. Rajasekhar has received competitive research awards from the Alexander von Humboldt Foundation, Germany, and the Robert A. Welch Foundation, Texas. He has conducted research at MD Anderson Cancer Center in Houston, University of California at Irvine, University of Freiburg in Germany, etc., and taught at the University of California, Irvine and the University of Medicine and Dentistry of New Jersey. Dr. Rajasekhar has served as a peer reviewer for several journals, including Stem Cells, Proceedings of National Academy of Sciences USA, Journal of Molecular Biology, Journal of Cell Biology, Neoplasia, etc.