CANCER EPIGENETICS. RISK ASSESSMENT, DIAGNOSIS, TREATMENT, AND PROGNOSIS

- Includes cutting-edge techniques in cancer epigenetic research.
- Provides step-by-step detail essential for reproducible results.
- Contains key notes and implementation advice from the experts.
This volumeshares technologies that detect common epigenetic changes which are very important in the early detection, progression, and prognosis of cancer as well as the design of new therapeutic tools against cancer cells. Beginning with a bit of background on epigenetic mechanisms, Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis continues with cancer specific type epigenetic change, methods and technologies used for detecting epigenetic changes, factors that influence epigenetic changes in cancer, as well as a final section on future directions in the field. Written for the highly successful Methods in Molecular Biology series, chapters in this volume include the kind of detailed implementation advice that guarantees easily reproducible results. Comprehensive and practical, Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis provides the most up-to-date knowledge of epigenetics and its implication in cancer prevention by risk assessment and screening and cancer control by treatment.

Table of contents (41 chapters)
1.Cancer Epigenetics: An Introduction
2.Community Resources and Technologies Developed Through the NIH Roadmap Epigenomics Program
3.Epigenome-Wide Association Studies (EWAS): Past, Present, and Future
4.Epigenetic Biomarkers in Liver Cancer
5.Cancer Type-Specific Epigenetic Changes: Gastric Cancer
6.Beyond the Island: Epigenetic Biomarkers of Colorectal and Prostate Cancer
7.Prostate Cancer Epigenome
8.CpG Island Hypermethylation as a Biomarker for the Early Detection of Lung Cancer
9.Analysis of DNA Methylation in Pancreatic Cancer: An Update
10.Epigenetics of Urothelial Carcinoma
11.Epigenetics of Prostate Cancer
12.Methylation Profile Landscape in Mesothelioma: Possible Implications in Early Detection, Disease Progression, and Therapeutic Options
13.Techniques to Access Histone Modifications and Variants in Cancer
14.Single Base Resolution Analysis of 5-Methylcytosine and 5-Hydroxymethylcytosine by RRBS and TAB-RRBS
15.Quantitative DNA Methylation Analysis for Epigenotyping of Colorectal Cancer
16.Histone Modifications Associated with Cancer Cell Migration and Invasion
17.Aberrant Epigenetic Modifications in Radiation-Resistant Head and Neck Cancers
18.Cancer-Associated Infectious Agents and Epigenetic Regulation
19.Toxicoepigenomics and Cancer: Implications for Screening
20.Human Papilloma Virus (HPV) Modulation of the HNSCC Epigenome
21.Epigenetic Regulation of HIV, AIDS, and AIDS-Related Malignancies
22.Epigenetics of Colorectal Cancer
23.Epigenetics in Breast and Prostate Cancer
24.Epigenetic Inhibitors
25.Use of Epigenetic Modulators as a Powerful Adjuvant for Breast Cancer Therapies
26.Epigenetic Approaches in Glioblastoma Multiforme and Their Implication in Screening and Diagnosis
27.Detection of Circulatory MicroRNAs in Prostate Cancer
28.Identification and Characterization of Small-Molecule Inhibitors of Lysine Acetyltransferases
29.Epigenetic Regulation in Biopsychosocial Pathways
30.Viral Epigenetics
31.P53 Tumor Suppression Network in Cancer Epigenetics
32.Promoter Hypermethylation as a Biomarker in Prostate Adenocarcinoma
33.Sequencing the Cancer Methylome
34.Global DNA Methylation Profiling Technologies and the Ovarian Cancer Methylome
35.Recent Progress in the Discovery of Epigenetic Inhibitors for the Treatment of Cancer
36.At the Crossroad Between Obesity and Gastric Cancer
37.Detection of Epigenetic Aberrations in the Development of Hepatocellular Carcinoma
38.Specific Type Epigenetic Changes in Cervical Cancers
39.Epigenetics in Head and Neck Cancer
40.Epigenetic Therapy for Colorectal Cancer
41.Epigenetics of Gastric Cancer