BIOLOGICS TO TREAT SUBSTANCE USE DISORDERS. VACCINES, MONOCLONAL ANTIBODIES, AND ENZYMES

1. Introduction: Biologics to Treat Substance Use Disorders: Vaccines, Monoclonal Antibodies, and Enzymes
2. Therapeutic Vaccines for Treating Nicotine Addiction
3. Vaccines for Treating Cocaine Use Disorders
4. Vaccines for Opioid Addiction
5. Vaccines for Methamphetamine Use Disorder
6. Cocaine and HIV Infection
7. Monoclonal Antibodies
8. Anti-cocaine Monoclonal Antibodies
9. Discovery and Development of an Anti-methamphetamine Monoclonal Antibody for Use in Treating Methamphetamine Abuse
10. Enzyme-Based Cocaine Pharmacotherapies: Current Status and Projections for the Future
11. Viral Gene Transfer of Enzymes
12. Cocaine Hydrolases Designed from Butyrylcholinesterase
13. Adenovirus-Based Vaccines for the Treatment of Substance Use Disorders
14. Nanoparticle-Based Nicotine Vaccine
15. Exploration of DNA Nanostructures for Rational Design of Vaccines
16. Adjuvants for Substance Abuse Vaccines
17. Skin Vaccination Against Nicotine Addiction
18. Hapten Design for Anti-addiction Vaccine Development
19. B Cell Mechanisms Underlying Vaccine Efficacy Against Drugs of Abuse
20. Practical Considerations for the Development of Vaccines Against Drugs of Abuse
21. Ethical Considerations of Biologics to Treat Substance Use Disorders

This book is a scientific compendium documenting the state of the art in the discovery and development of vaccines, monoclonal antibodies, and enzymes for the treatment of Substance Use Disorders (SUDs). The book gives detailed consideration to some of the most cutting edge topics in addiction medicine, including vaccines for nicotine, cocaine, heroin, and methamphetamine dependence; monoclonal antibodies against cocaine, methamphetamine, and phencyclidine; and the enzymes butyrylcholinesterase and cocaine esterase. In addition, the text covers a wide range of new strategies designed to optimize the development and efficacy of biologics. Unlike any other resource, this book reviews how biologics offer exciting new therapeutic opportunities for various psychiatric conditions.
Written by experts in the field, Biologics to Treat Substance Use Disorders is as an authoritative reference for psychiatrists, psychologists, and all other medical professionals working with patients suffering from Substance Use Disorders.

Features
• Covers all aspects of vaccines and other biologics employed for treatment of substance use disorders
• Discusses novel strategies to optimize the development and efficacy of biologics
• Written and edited by experts in the field

Author
Ivan D. MontoyaNational Institutes of Health, Bethesda, USA