BASIC PHARMACOKINETICS AND PHARMACODYNAMICS: AN INTEGRATED TEXTBOOK AND COMPUTER SIMULATIONS, 2ND EDITION

1 Introduction to Pharmacokinetics and Pharmacodynamics 1
2 Passage of Drugs Through Membranes 19
3 Drug Administration and Drug Absorption 35
4 Drug Distribution 71
5 Drug Elimination and Clearance 99
6 Compartmental Models in Pharmacokinetics 145
7 Pharmacokinetics of an Intravenous Bolus Injection in a One-Compartment Model 159
8 Pharmacokinetics of an Intravenous Bolus Injection in a Two-Compartment Model 177
9 Pharmacokinetics of Extravascular Drug Administration 201
10 Introduction to Noncompartmental Analysis 225
11 Pharmacokinetics of Intravenous Infusion in a One-Compartment Model 237
12 Multiple Intravenous Bolus Injections in the One-Compartment Model 255
13 Multiple Intermittent Infusions 279
14 Multiple Oral Doses 293
15 Nonlinear Pharmacokinetics 303
16 Introduction to Pharmacogenetics 323
17 Models Used to Predict Drug–Drug Interactions for Orally Administered Drugs 337
18 Introduction to Physiologically Based Pharmacokinetic Modeling 367
19 Introduction to Pharmacodynamic Models and Integrated Pharmacokinetic–Pharmacodynamic Models 391
20 Semimechanistic Pharmacokinetic–Pharmacodynamic Models 413

Appendix A Review of Exponents and Logarithms 469
Appendix B Rates of Processes 479
Appendix C Creation of Excel Worksheets for Pharmacokinetic Analysis 489
Appendix D Derivation of Equations for Multiple Intravenous Bolus Injections 505
Appendix E Enzyme Kinetics: Michaelis–Menten Equation and Models for Inhibitors and Inducers of Drug Metabolism 509
Appendix F Summary of the Properties of the Fictitious Drugs Used in the Text 527
Appendix G Computer Simulation Models 529

Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action.
• Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner
• Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules
• Features interactive computer simulations, available online through a companion website at: http://www.uri.edu/pharmacy/faculty/rosenbaum/basicmodels.html
• Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications
• Reviews of the 1st edition: “This is an ideal textbook for those starting out … and also for use as a reference book …." (International Society for the Study of Xenobiotics) and “I could recommend Rosenbaum’s book for pharmacology students because it is written from a perspective of drug action . . . Overall, this is a well-written introduction to PK/PD …. “ (British Toxicology Society Newsletter)

Author Information
Sara E. Rosenbaum, PhD, is Professor of Biomedical and Pharmaceutical Sciences at the University of Rhode Island, where she teaches courses in pharmacokinetics and pharmacodynamics. Her research interests concentrate on the development and application of pharmacokinetic and pharmacodynamic models to better understand the drug dose-response relationship.